What are the contraindications of ondansetron?
Ondansetron tablets are contraindicated in patients: known to have hypersensitivity (e.g., anaphylaxis) to Ondansetron or any of the components of the formulation [see Adverse Reactions (6.2)] receiving concomitant apomorphine due to the risk of profound hypotension and loss of consciousness.
What happens if you give ondansetron too fast?
Do not give this medication any faster than recommended or take more than the recommended dose because this may increase the chance of serious side effects such as blurred vision or slowed/irregular heartbeat.
Is ondansetron and ondansetron HCl the same?
Each 16 mg ondansetron hydrochloride tablet for oral administration contains ondansetron HCl dihydrate equivalent to 16 mg of ondansetron.
Is ondansetron given slowly?
The recommended intravenous dose of ondansetron is 8 mg administered as a slow injection (in not less than 30 seconds) or as an infusion over 15 minutes immediately before treatment, followed by treatment with dosage forms other than intravenous.
What is the side effects of ondansetron?
What side effects can this medication cause?
- headache.
- constipation.
- weakness.
- tiredness.
- chills.
- drowsiness.
Why is ondansetron restricted?
Ondansetron (Zofran): important new intravenous dose restriction. New maximum single intravenous dose of ondansetron for the management of chemotherapy-induced nausea and vomiting (CINV) restricted due to risk of QTc prolongation.
Can you take Zofran on an empty stomach while pregnant?
Ondansetron can be taken with or without food.
What medication is used for nausea and vomiting in pregnancy?
Dimenhydrinate, meclizine, and diphenhydramine are the antihistamines that have been most extensively studied for treatment of nausea and vomiting of pregnancy.
Can you drink water with ondansetron?
Ondansetron can be taken with or without food. The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor’s dosing instructions very carefully. Take the ondansetron regular tablet with a full glass of water.
Does ondansetron cause birth defects?
Main Findings. For most of the birth defects studied, researchers found that taking ondansetron during early pregnancy did not appear to increase the chance of having a baby with a birth defect. Women should discuss options for managing nausea and vomiting symptoms during pregnancy with their healthcare providers.
What is ondansetron used to treat?
Ondansetron’s primary indication is for treatment of nausea and vomiting associated with chemotherapy or surgery. It is available as a tablet, an oral disintegrating tablet, an oral solution, and intravenously, which makes it a useful candidate for treating women with intractable vomiting.
How is nausea and vomiting of pregnancy and hyperemesis gravidarum treated?
Nausea and vomiting and hyperemesis gravidarum typically occur during the first trimester, the sensitive time for exposure to teratogens because organogenesis is occurring in the embryo. An efficacious treatment used widely across the United States for both nausea and vomiting of pregnancy and hyperemesis gravidarum is ondansetron.
Is it safe to use amitriptyline during pregnancy?
-If use is absolutely necessary, caution should be exercised, especially during the first trimester. Animal studies have failed to reveal evidence of harm to the embryo, fetus, gestation period, perinatal/postnatal development, and/or fertility.