What is Macroduct?
The Macroduct system is the Webster Sweat Inducer, and the Macroduct Sweat Collector. Together they have revolutionized the laboratory sweat test for cystic fibrosis, and have brought early intervention to thousands of CF patients around the world. With the Macroduct system, sweat testing is both accurate and simple.
What is sweat collection by iontophoresis?
An electric current introduces the sweat inducing drug (Pilocarpine Nitrate) into a. selected clean skin area. A macroduct sweat collector is placed on the patient’s limb. and covered to insure that it is airtight. After 30 minutes, the tubing is plugged, and the.
How do you collect sweat chloride?
Sweat Chloride Sample Collection The patient’s skin (usually the forearm) is washed with water and patted dry. A pad soaked in pilocarpine (chemical that stimulates sweat glands) is placed on the skin. An electrode creates a mild current that moves the chemical through the skin into the area where the sweat glands are.
What is the minimum acceptable sweat yield for a valid test collected in 30 minutes using the Macroduct coil method?
Sweat is collected for no longer than 30 minutes. During this time period, at least 15 µL of sweat in Macroduct® coils (shown on the right) or 75 mg of sweat on 2×2 inch gauze or filter paper must be collected to reflect an appropriate sweat rate needed to yield an accurate diagnosis.
What is the efficient method for sweat collection and stimulation?
Currently there are two accepted techniques for sweat stimulation and collection in the clinical settings: Gibson and Cook technique (GCT) and Wescor Macroduct collection system (8, 9).
How do you test for cystic fibrosis?
There are two tests commonly used to diagnose cystic fibrosis (CF): a sweat test, which measures the amount of chloride in sweat, and a genetic test, which detects chromosomal mutations associated with the disease. Because of the severity of CF and the need for proactive treatment, newborns are routinely screened.
How much does a sweat chloride test cost?
Sweat chloride testing costs approximately $250, while the genetic testing can cost $3,000 or more. An estimated $500,000 was spent on unnecessary mutation analysis.
Is there any cure for cystic fibrosis?
There is no cure for cystic fibrosis, but treatment can ease symptoms, reduce complications and improve quality of life. Close monitoring and early, aggressive intervention is recommended to slow the progression of CF , which can lead to a longer life.
How do you collect sweat?
The collection is either via absorption of the sweat into a piece of gauze or filter paper, or by a collection device which funnels the sweat into a small plastic tube as it’s produced.
How long does a sweat chloride test take?
The sweat is then collected on a piece of filter paper or gauze or in a plastic coil. This step lasts for 30 minutes. The collected sweat is then sent to a hospital laboratory to measure how much chloride is in the sweat — usually later the same day. The sweat test usually takes about an hour, but it may take longer.
What is sweat inducer?
The Webster Sweat Inducer is an improved, lightweight unit that accomplishes pilocarpine iontophoresis simply by activat- ing a start switch. It automatically delivers a safe and optimal quantity of pilocarpine for gland stimulation (equivalent to five minutes iontophoresis at 1.5 mA).
How long can you live with cystic fibrosis?
Today, the average life span for people with CF who live to adulthood is about 44 years. Death is most often caused by lung complications.
What is the macroduct sweat test?
Standardized sweat testing for the laboratory diagnosis of cystic fibrosis. The Macroduct system is the Webster Sweat Inducer, and the Macroduct Sweat Collector. Together they have revolutionized the laboratory sweat test for cystic fibrosis, and have brought early intervention to thousands of CF patients around the world.
How does the macroduct work?
The Macroduct is placed over the iontophoretically-stimulated area on the skin and firmly strapped in place. Sweat secreted by the sweat glands is forced from the ducts under hydraulic pressure and flows between the skin and the concave undersurface of the Macroduct collector and into the micro bore tubing spiral.
How does the Webster sweat inducer work?
With the Macroduct system, sweat testing is both accurate and simple. Sweat Testing consists of three separate procedures, the first one being sweat stimulation. The improved Webster Sweat Inducer accomplishes pilocarpine iontophoresis simply by activating a start switch.
What is the best method for sweat testing?
With the Macroduct system, sweat testing is both accurate and simple. The 1959 pad absorption method of Gibson and Cooke, which introduced pilocarpine iontophoresis for sweat stimulation, is generally regarded as the reference method for sweat testing.