What is nsp1p P?

What is nsp1p P?

Nsp1 p is one of a group of nucleoporins that contain multiple repeats of the amino acids FXFG; deletion of the FXFG repeats has no effect on cell viability ( 6, 13, 14 ). Nsp1 p shows sequence similarity to a nucleoporin, p62, found in NPCs from higher eukaryotes such as human ( 34) and rat ( 14 ).

What is the nuclear pore protein NSP1?

NSP1 encodes an essential nuclear pore protein ( 1, 6, 13, 14 ). Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complex (NPC), a large macromolecular complex that spans the nuclear envelope (reviewed in 14, 13, 15, 16 ).

What does NSP1 P bind to in vitro?

Nsp1 p also binds to the small GTPase Gsp1 p in vitro ( 32 ), and can associate with the importin Pse1 p ( 33 ). Nsp1 p is one of a group of nucleoporins that contain multiple repeats of the amino acids FXFG; deletion of the FXFG repeats has no effect on cell viability ( 6, 13, 14 ).

Where is nicnsp1 P found?

Nsp1 p is found in a subcomplex of the NPC that also contains Nup49 p, Nup57 p, and Nic96 p ( 14, 29, 30 ). This complex has been detected at both the nuclear and cytoplasmic periphery of the NPC central channel ( 2 ). A second complex containing Nsp1 p and Nup82 p ( 31) is found only at the cytoplasmic periphery of the channel ( 2 ).