What is use of dabigatran etexilate capsules?

What is use of dabigatran etexilate capsules?

Dabigatran is used to prevent stroke and harmful blood clots (such as in your legs or lungs) if you have a certain type of irregular heartbeat (atrial fibrillation).

How is dabigatran metabolized?

Dabigatran is metabolized via conjugation into four acyl glucuronides, each of which is a direct thrombin inhibitor with less than 10% of the activity of the parent compound [23]. Dabigatran neither is metabolized by nor induces any cytochrome P450 subtype [22].

What is dabigatran etexilate mesylate?

Pradaxa (dabigatran) is an anticoagulant that works by blocking the clotting protein thrombin. Pradaxa is used to prevent blood clots from forming because of a certain irregular heart rhythm (atrial fibrillation). Preventing these blood clots helps to reduce the risk of a stroke.

Does dabigatran cause weight gain?

more common with dabigatran than with warfarin were weight gain, fluid retention, and insomnia (Table 3).

How long does it take for dabigatran to work?

How long does it take for dabigatran to work? Dabigatran begins to reduce blood clotting within a few hours after you take the first dose. If you stop taking dabigatran, its effects on clotting begin to wear off within 24 hours for most people.

Should dabigatran be taken with food?

It’s usual to take dabigatran twice a day. You can take dabigatran with or without food. The most common side effect of dabigatran is bleeding more easily than normal, such as having nosebleeds, bleeding gums and bruising. It tends to happen in the first few weeks of treatment or if you’re unwell.

How does dabigatran work?

They work with blood cells called platelets that trigger the clotting process to make sure your blood clots properly. Dabigatran works by stopping a clotting factor called thrombin from working. This thins your blood so it takes longer to clot.

Where is dabigatran absorbed?

Dabigatran is thought to be absorbed in the lower stomach and duodenum because of the rapid time to peak levels 21.

What are the side effects of dabigatran?

Side Effects

  • Acid or sour stomach.
  • belching.
  • black, tarry stools.
  • bloody stools.
  • pain or burning in the throat.
  • stomach discomfort, upset, burning, or pain.
  • vomiting of blood or material that looks like coffee grounds.

Which is better aspirin or dabigatran?

Conclusions: Dabigatran was putatively associated with a lower relative risk of recurrent stroke compared with aspirin in Japanese ESUS patients. Keywords: Anticoagulation; Aspirin; Dabigatran; Ischemic stroke; Stroke recurrence.

How should dabigatran be taken?

The usual dose of dabigatran is a 150-mg capsule twice a day by mouth. For people with certain types of kidney problems, the dose may be decreased to 75 mg twice a day. The dabigatran capsule may be taken with or without food and must be swallowed whole.

Can I take vitamin D with dabigatran?

Interactions between your drugs No interactions were found between Pradaxa and Vitamin D3.

What are the ingredients in dabigatran etexilate mesylate?

The 150 mg capsule for oral administration contains 172.95 mg dabi gatran etexilate mesylate, which is equivalent to 150 mg of dabigatran etexilate, and the following inactive ingredients: acacia, dimethicone, hypromellose, hydroxypropyl cellulose, talc, and tartaric acid.

What happens if dabigatran etexilate capsules are discontinued?

If anticoagulation with Dabigatran Etexilate Capsules is discontinued for a reason other than pathological bleeding or completion of a course of therapy, consider coverage with another anticoagulant [see Dosage and Administration (2.4, 2.5, 2.6) and Warnings and Precautions (5.1)].

How many mg of dabigatran should I take for high creatinine?

Reduce dose to 75 mg twice daily if given with P-gp inhibitors dronedarone or systemic ketoconazole. For patients with creatinine clearance (CrCl) >30 mL/min, the recommended dose of Dabigatran Etexilate Capsules is 150 mg taken orally, twice daily.

What is the recommended dose of dabigatran etexilate for dialysis patients?

Dosing recommendations for patients with a CrCl ≤30 mL/min or on dialysis cannot be provided [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. For patients with CrCl >30 mL/min, the recommended dose of Dabigatran Etexilate Capsules is 150 mg taken orally, twice daily after previous treatment.